New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
نویسندگان
- Yingchang Lu
- Felix R Day
- Stefan Gustafsson
- Martin L Buchkovich
- Jianbo Na
- Veronique Bataille
- Diana L Cousminer
- Zari Dastani
- Alexander W Drong
- Tõnu Esko
- David M Evans
- Mario Falchi
- Mary F Feitosa
- Teresa Ferreira
- Åsa K Hedman
- Robin Haring
- Pirro G Hysi
- Mark M Iles
- Anne E Justice
- Stavroula Kanoni
- Vasiliki Lagou
- Rui Li
- Xin Li
- Adam Locke
- Chen Lu
- Reedik Mägi
- John R B Perry
- Tune H Pers
- Qibin Qi
- Marianna Sanna
- Ellen M Schmidt
- William R Scott
- Dmitry Shungin
- Alexander Teumer
- Anna A E Vinkhuyzen
- Ryan W Walker
- Harm-Jan Westra
- Mingfeng Zhang
- Weihua Zhang
- Jing Hua Zhao
- Zhihong Zhu
- Uzma Afzal
- Tarunveer Singh Ahluwalia
- Stephan J L Bakker
- Claire Bellis
- Amélie Bonnefond
- Katja Borodulin
- Aron S Buchman
- Tommy Cederholm
- Audrey C Choh
- Hyung Jin Choi
- Joanne E Curran
- Lisette C P G M de Groot
- Philip L De Jager
- Rosalie A M Dhonukshe-Rutten
- Anke W Enneman
- Elodie Eury
- Daniel S Evans
- Tom Forsen
- Nele Friedrich
- Frédéric Fumeron
- Melissa E Garcia
- Simone Gärtner
- Bok-Ghee Han
- Aki S Havulinna
- Caroline Hayward
- Dena Hernandez
- Hans Hillege
- Till Ittermann
- Jack W Kent
- Ivana Kolcic
- Tiina Laatikainen
- Jari Lahti
- Irene Mateo Leach
- Christine G Lee
- Jong-Young Lee
- Tian Liu
- Youfang Liu
- Stéphane Lobbens
- Marie Loh
- Leo-Pekka Lyytikäinen
- Carolina Medina-Gomez
- Karl Michaëlsson
- Mike A Nalls
- Carrie M Nielson
- Laticia Oozageer
- Laura Pascoe
- Lavinia Paternoster
- Ozren Polašek
- Samuli Ripatti
- Mark A Sarzynski
- Chan Soo Shin
- Nina Smolej Narančić
- Dominik Spira
- Priya Srikanth
- Elisabeth Steinhagen-Thiessen
- Yun Ju Sung
- Karin M A Swart
- Leena Taittonen
- Toshiko Tanaka
- Emmi Tikkanen
- Nathalie van der Velde
- Natasja M van Schoor
- Niek Verweij
- Alan F Wright
- Lei Yu
- Joseph M Zmuda
- Niina Eklund
- Terrence Forrester
- Niels Grarup
- Anne U Jackson
- Kati Kristiansson
- Teemu Kuulasmaa
- Johanna Kuusisto
- Peter Lichtner
- Jian'an Luan
- Anubha Mahajan
- Satu Männistö
- Cameron D Palmer
- Janina S Ried
- Robert A Scott
- Alena Stancáková
- Peter J Wagner
- Ayse Demirkan
- Angela Döring
- Vilmundur Gudnason
- Douglas P Kiel
- Brigitte Kühnel
- Massimo Mangino
- Barbara Mcknight
- Cristina Menni
- Jeffrey R O'Connell
- Ben A Oostra
- Alan R Shuldiner
- Kijoung Song
- Liesbeth Vandenput
- Cornelia M van Duijn
- Peter Vollenweider
- Charles C White
- Michael Boehnke
- Yvonne Boettcher
- Richard S Cooper
- Nita G Forouhi
- Christian Gieger
- Harald Grallert
- Aroon Hingorani
- Torben Jørgensen
- Pekka Jousilahti
- Mika Kivimaki
- Meena Kumari
- Markku Laakso
- Claudia Langenberg
- Allan Linneberg
- Amy Luke
- Colin A Mckenzie
- Aarno Palotie
- Oluf Pedersen
- Annette Peters
- Konstantin Strauch
- Bamidele O Tayo
- Nicholas J Wareham
- David A Bennett
- Lars Bertram
- John Blangero
- Matthias Blüher
- Claude Bouchard
- Harry Campbell
- Nam H Cho
- Steven R Cummings
- Stefan A Czerwinski
- Ilja Demuth
- Rahel Eckardt
- Johan G Eriksson
- Luigi Ferrucci
- Oscar H Franco
- Philippe Froguel
- Ron T Gansevoort
- Torben Hansen
- Tamara B Harris
- Nicholas Hastie
- Markku Heliövaara
- Albert Hofman
- Joanne M Jordan
- Antti Jula
- Mika Kähönen
- Eero Kajantie
- Paul B Knekt
- Seppo Koskinen
- Peter Kovacs
- Terho Lehtimäki
- Lars Lind
- Yongmei Liu
- Eric S Orwoll
- Clive Osmond
- Markus Perola
- Louis Pérusse
- Olli T Raitakari
- Tuomo Rankinen
- D C Rao
- Treva K Rice
- Fernando Rivadeneira
- Igor Rudan
- Veikko Salomaa
- Thorkild I A Sørensen
- Michael Stumvoll
- Anke Tönjes
- Bradford Towne
- Gregory J Tranah
- Angelo Tremblay
- André G Uitterlinden
- Pim van der Harst
- Erkki Vartiainen
- Jorma S Viikari
- Veronique Vitart
- Marie-Claude Vohl
- Henry Völzke
- Mark Walker
- Henri Wallaschofski
- Sarah Wild
- James F Wilson
- Loïc Yengo
- D Timothy Bishop
- Ingrid B Borecki
- John C Chambers
- L Adrienne Cupples
- Abbas Dehghan
- Panos Deloukas
- Ghazaleh Fatemifar
- Caroline Fox
- Terrence S Furey
- Lude Franke
- Jiali Han
- David J Hunter
- Juha Karjalainen
- Fredrik Karpe
- Robert C Kaplan
- Jaspal S Kooner
- Mark I McCarthy
- Joanne M Murabito
- Andrew P Morris
- Julia A N Bishop
- Kari E North
- Claes Ohlsson
- Ken K Ong
- Inga Prokopenko
- J Brent Richards
- Eric E Schadt
- Tim D Spector
- Elisabeth Widén
- Cristen J Willer
- Jian Yang
- Erik Ingelsson
- Karen L Mohlke
- Joel N Hirschhorn
- John Andrew Pospisilik
- M Carola Zillikens
- Cecilia Lindgren
- Tuomas Oskari Kilpeläinen
- Ruth J F Loos
چکیده
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.
منابع مشابه
Does body adiposity index evaluate percentage of body fat?
Introduction: The purpose of the present study was to determine whether the novel marker, body adiposity index (BAI), is accurate to measure percentage of body fat (PBF). Materials and methods: Seventy-eight males were undergone anthropometric examination. PBF was calculated by BAI and measured using InBody 3.0. Results: Significant correlation was found between BAI and PBF (r = 0.751; P < ...
متن کاملThe relative contributions of the abdominal visceral and subcutaneous fat depots to cardiometabolic risk in youth.
The aim of this study was to evaluate the association of abdominal visceral and subcutaneous fat, independent of total body fat, with cardiometabolic risk factors and insulin resistance among youth. Visceral and subcutaneous fat, percentage total body fat, insulin resistance (adjusted for lean body mass: Mlbm), blood pressure, glucose, insulin and lipids were obtained in 472 youth ages 6-18 yea...
متن کاملEvaluation of Bioelectrical Impedance Analysis for Identifying Overweight Individuals at Increased Cardiometabolic Risk: A Cross-Sectional Study
OBJECTIVE To investigate whether bioelectrical impedance analysis could be used to identify overweight individuals at increased cardiometabolic risk, defined as the presence of metabolic syndrome and/or diabetes. DESIGN AND METHODS Cross-sectional study of a Scottish population including 1210 women and 788 men. The diagnostic performance of thresholds of percentage body fat measured by bioele...
متن کاملIs vulnerability to cardiometabolic disease in Indians mediated by abdominal adiposity or higher body adiposity
BACKGROUND Indians may be particularly vulnerable to cardiometabolic disease, potentially due to higher body fat for a given BMI, or a tendency towards depositing abdominal adiposity. The aim of the study is to assess whether different measures of the distribution of adiposity (abdominal versus whole body) or amount of adiposity (DXA versus traditional anthropometric) are better at predicting p...
متن کاملBioelectrical Impedance versus Body Mass Index for Predicting Body Composition Parameters in Sedentary Job Women
Objective: Nowadays the value of bioelectrical impedance analysis (BIA) in the estimation of body adiposity both on a clinical basis in the individual and epidemiologically in large populations is of great interest. The current study determine accuracy of BIA compared with body mass index (BMI) measurement for estimating body composition in a group of normal weight employee women with a sedenta...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
دوره 7 شماره
صفحات -
تاریخ انتشار 2016